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Hydrocortison Orion

Hydrocortison Orion

hydrocortisone

Manufacturer:

Orion Pharma

Distributor:

Apex
Concise Prescribing Info
Contents
Hydrocortisone
Indications/Uses
Adrenocortical insufficiency (Addison's disease), hypopituitarism, congenital adrenal hyperplasia. Conditions where systemic glucocorticoid therapy is indicated.
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Dosage/Direction for Use
Adult Substitution therapy 20-30 mg daily. Other indications 40-200 mg daily. Higher doses: In short-term use for special indications. Childn Adrenocortical insufficiency 7.5-15 mg/m2 daily in 3 equal doses. Congenital adrenal hyperplasia 10 mg/m2 daily in 3 divided doses. Hypopituitarism 2.5 mg tds.
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Overdosage
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Administration
Should be taken with food.
Contraindications
Hypersensitivity. TB, other acute or chronic bacterial & viral infections w/o antibiotic or chemotherapeutic protection.
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Special Precautions
Stress, situations eg, trauma, infections or surgery; acute psychosis, peptic ulcer, diabetes, osteoporosis, glaucoma, HTN. Avoid abrupt w/drawal. Concomitant use w/ live virus vaccine. Long-term systemic glucocorticoid therapy. Pregnancy & lactation.
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Adverse Reactions
Mineralocorticoid effect; adrenocortical insufficiency; fever, myalgia, arthralgia, weakness, nausea, elevated ICP, hypotension; Cushing's syndrome; increased susceptibility to infections, prolonged tissue healing & scar formation; osteoporosis, diabetes, cataract, elevated IOP, aseptic bone necrosis, nephroliths, muscle weakness, skin atrophy, tendency to thromboses, hypokalemia, hyperlipidemia, increased appetite; gastric ulcer; psychiatric reactions eg, depression, psychosis, insomnia; allergy & anaphylactic reactions; aggravate cardiac insufficiency & HTN.
Drug Interactions
Increased clearance by phenytoin, phenobarb, carbamazepine, rifampicin, antithyroid drugs. Weakened effects of anticoagulants, antidiabetics. Muscle weakness w/ anticholinesterases. Increased risk of hypokalemia w/ diuretics, amphotericin B. Increased risk of anti-inflammatory analgesic-induced peptic ulcer.
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Storage
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Description
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Action
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MIMS Class
Corticosteroid Hormones
ATC Classification
H02AB09 - hydrocortisone ; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations.
Presentation/Packing
Form
Hydrocortison Orion tab 10 mg
Packing/Price
100's
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